rev_Supplementary_Figures_DC19-2289.docx (1.5 MB)

The association of energy and macronutrients intake at dinner versus breakfast with disease-specific and all-cause mortality among people with diabetes: the US National Health and Nutrition Examination Survey, 2003-2014

Download (1.5 MB)
figure
posted on 04.06.2020 by Tianshu Han, Jian Gao, Lihong Wang, Chao Li, Lu Qi, Changhao Sun, Ying Li
Objective This study aims to evaluate the association of energy and macronutrients intake at dinner vs. breakfast with disease-specific and all-cause mortality in people with diabetes.

Methods 4699 peoples with diabetes who enrolled in the National Health and Nutrition Examination Survey from 2003 to 2014 were recruited for this study. Energy and macronutrients intake were measured by a 24h dietary-recall. The Differences(△) in energy and macronutrients intake between dinner and breakfast (△=dinner minus breakfast) were categorized into quintiles. Death information was obtained from the National Death Index until 2015. Cox proportional hazards regression models were developed to evaluate the survival relationship between △ and diabetes, cardiovascular-disease (CVD) and all-cause mortality.

Results Of the 4699 participants, 913 deaths, including 269 deaths due to diabetes and 314 deaths due to CVD, were documented. After adjusting for potential confounders, compared with participants in the lowest quintile of Δ in terms of total energy and protein, participants in the highest quintile were more likely to die due to diabetes (HRΔenergy=1.92, 99% CI:1.08-3.42; HRΔprotein=1.92, 99% CI:1.06-3.49) and CVD (HRΔenergy=1.69, 99% CI:1.02-2.80; HRΔprotein=1.96, 99% CI:1.14-3.39). The highest quintile of Δ from total-fat was related with CVD mortality (HR=1.67, 99% CI: 1.01-2.76). Isocalorically replacing 5% of total-energy at dinner with breakfast was associated with 4% and 5% lower risk of diabetes (HR=0.96, 95% CI: 0.94-0.98) and CVD (HR=0.95, 95% CI: 0.93-0.97) mortality.

Conclusions Higher intake of energy, total-fat and protein from dinner than breakfast was associated with greater diabetes, CVD and all-cause mortality in people with diabetes.

Funding

This research was supported by funds from the National Key R&D Program of China (2017YFC1307401 to Changhao Sun) and the National Natural Science Foundation (81803227 to Tianshu Han).

History

Exports

Logo branding

Exports