<b>Obstructive Sleep Apnea, Resting Heart Rate and Glycemic Variability in Adults with Maturity-Onset Diabetes of the Young</b>

<p dir="ltr">Obstructive sleep apnea (OSA) is a common condition strongly linked to increased cardiovascular risk and poor glycemic control. Little is known about OSA, cardiovascular risk and glycemia in maturity onset diabetes of the young (MODY), an inherited form of diabetes, which is different than both type 1 and type 2 diabetes. We assessed OSA, resting heart rate (RHR), an important prognostic marker of cardiovascular disease, and glycemic variability among the most common subtypes of MODY, glucokinase (GCK)-MODY and transcription factor (TF)-related MODY (HNF1A, HNF4A and HNF1B). Adults with GCK-MODY (n=63) and TF-related MODY (n=60), and controls without diabetes (n=65) were screened for OSA by home sleep test. Glycemic variability (continuous glucose monitoring) and RHR (wearable sleep-activity tracker) were concomitantly assessed for 2 weeks at home. Data from 188 subjects (2853 recorded days) were analyzed. TF-related MODY, compared to GCK-MODY or controls, had more OSA (48.3%, 27.0% and 30.8%, respectively; p=0.033), higher RHR (72.8±10.8, 65.2±7.9 and 67.3±7.7 bpm, respectively; p<0.001), and higher glycemic variability (coefficient of variation of glucose 31.6±6.0%, 17.3±4.5% and 17.5±4.0%, respectively; p<0.001). Greater severity of OSA and higher RHR were associated with higher glycemic variability. These findings may have important clinical implications for cardiovascular risk assessment in MODY.</p>