<b>Longitudinal Associations of PFAS Exposure </b><b>with Insulin Sensitivity and β-cell Function </b><b>among Hispanic Women with Gestational Diabetes Mellitus History</b>

<p dir="ltr"><u>Objective</u></p><p dir="ltr"><a href="" target="_blank">We investigated associations between per- and polyfluoroalkyl substances (PFAS) and changes in diabetes indicators from pregnancy to 12 years after delivery among women with gestational diabetes mellitus (GDM) history.</a></p><p dir="ltr"><u>Research Design and Methods</u></p><p dir="ltr">Eighty Hispanic women with GDM history were followed from third trimester of pregnancy to 12 years after delivery. Oral and intravenous glucose tolerance tests were conducted during follow-up. Plasma PFAS concentrations were measured at third trimester of pregnancy and first postpartum visit. Linear mixed-effects model analyzed associations between PFAS and trajectories of diabetes indicators, adjusted for age, breastfeeding status, total calories, and body fat percentage.</p><p dir="ltr"><u>Results</u></p><p dir="ltr">Increased MeFOSAA was associated with faster increase in fasting glucose (p=0.003). Increased PFNA and n-PFOA were associated with faster increase in fasting insulin (=0.04,=0.02) and faster decrease in AIRg (=0.04,=0.02).</p><p dir="ltr"><u>Conclusion</u></p><p dir="ltr">PFAS exposure is associated with glucose intolerance, insulin resistance, and β-cell dysfunction, increasing type 2 diabetes risk.<br></p>