Isolated Glucosuria in Adolescence and Early-Onset Diabetes: A Nationwide Cohort Study of 1.6 million Adolescents

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posted on 2025-02-26, 17:59 authored by Adi Vinograd, Tsahi T. Lerman, Orit Pinhas-Hamiel, Aya Bardugo, Cole D. Bendor, Estela Derazne, Josef Coresh, Ofir Vinograd, Miri Lutski, Inbar Zucker, Michal Bromberg, Tamar Fishman, Gabriel Chodick, Hertzel C Gerstein, Asaf Vivante, Adi Leiba, Arnon Afek, Amir Tirosh, Boris Fishman, Gilad Twig

Objective Assessing diabetes risk in adulthood among adolescents with isolated glucosuria. Research Design and Methods Included were adolescents (16-19 years) examined before military service between 1993-2015. Data were linked with the Israeli National Diabetes Registry. Glucosuria was confirmed following normal renal function and glucose tolerance tests. Cox models were applied. Results The study included 1,611,467 adolescents, of whom 755 (0.05%) had glucosuria. The latter group had a higher proportion of males (75% vs 57%) and a lower proportion of BMI≥85th percentile (10.4% vs 16.3%) compared to non-glucosuric (all P <0.001). During follow-up, 10,328 diabetes cases were recorded with an incidence rate of 87.5 and 43.3 per 100,000 person-years for those with vs. without glucosuria, respectively. Individuals with glucosuria had an adjusted HR of 2.17 (95%CI, 1.17–4.04) for diabetes. Conclusions Glucosuria in adolescents is associated with an increased risk of early onset diabetes.