Utilizing Continuous Glucose Monitoring for Early Detection of Gestational Diabetes and Pregnancy Outcomes in an Asian Population

<p dir="ltr"><u>Objective</u></p><p dir="ltr">We explored continuous glucose monitoring’s (CGM) potential value in early pregnancy in predicting gestational diabetes mellitus (GDM) and pregnancy outcomes.</p><p dir="ltr"><u>Research Design and Methods</u></p><p dir="ltr">One hundred and three multi-ethnic Asian pregnant women with overweight/obesity were recruited from a hospital-based, prospective cohort. All of them had worn blinded CGM devices in early pregnancy and underwent the universal GDM screening at 24-28 gestation weeks. Models were selected based on early pregnancy risk factors and CGM-derived parameters to compare their respective predictive values for GDM and pregnancy outcomes.</p><p dir="ltr"><u>Results</u></p><p dir="ltr">Eighteen GDM cases were ascertained. CGM-derived novel parameters demonstrated greater performance (e.g., AUC: 0.953 vs. 0.722) for predicting incident GDM, compared with the model using traditional risks. Such novel CGM-derived parameters significantly differentiated primary cesarean and large-for-gestational-age babies.</p><p dir="ltr"><u>Conclusions</u></p><p dir="ltr">Our data suggests CGM's potential clinical utility in the first trimester for predicting GDM and adverse pregnancy outcomes, particularly in overweight or obese individuals.</p>