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The effect of BMI and type 2 diabetes on socioeconomic status: a two-sample multivariable Mendelian randomization study

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posted on 07.01.2021, 21:09 by Sara Pedron, Christoph F Kurz, Lars Schwettmann, Michael Laxy
OBJECTIVE

To assess the independent causal effect of BMI and type 2 diabetes (T2D) on socioeconomic outcomes applying two-sample Mendelian randomization (MR) analysis.

RESEARCH DESIGN AND METHODS

We carried out univariate and multivariate two-sample MR to jointly assess the effect BMI and T2D on socioeconomic outcomes. We used overlapping genome-wide significant single nucleotide polymorphisms (SNPs) for BMI and T2D as instrumental variables. Their causal impact on household income and regional deprivation was assessed using summary-level data from the UK Biobank.

RESULTS

In the univariate analysis, higher BMI was related with lower income (marginal effect of 1-SD increase in BMI [β=-0.092 (95% CI: -0.138; -0.047)] and higher deprivation [β=0.051 (95% CI: 0.022; 0.079)]. In the multivariate MR, the effect of BMI controlling for diabetes was slightly lower for income and deprivation. Diabetes was not associated with these outcomes.

CONCLUSIONS

High BMI, but not diabetes, shows a causal link with socioeconomic outcomes.

Funding

None.

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