The Nonlinear Relationship Between Psoas Cross-sectional Area and BMI: A New Observation and Its Insights into Diabetes Remission After Roux-en-Y Gastric Bypass

OBJECTIVE <p>To<a> explore the potential relevance of muscle mass as a variable contributor to body mass index (BMI) on BMI limitations in predicting diabetes remission (DR) after Roux-en-Y gastric bypass (RYGB). </a></p> <p> </p> <p>RESEARCH DESIGN AND METHODS</p> <p>We evaluated the relationship between muscle mass and BMI in 501 patients with type 2 diabetes mellitus and overweight or obesity. Of which <a>186 patients who underwent R</a>YGB were <a>studied to determine the role of baseline muscle mass </a><a>and BMI </a>in predicting DR. Muscle mass was assessed by estimated fat-free mass index (eFFMI) and psoas cross-sectional area (CSA).</p> <p> </p> <p>RESULTS</p> <p>A non-linear relationship existed between psoas CSA and BMI, whereas psoas CSA showed a highly positive correlation with <a>eFFMI</a>. Baseline psoas CSA and eFFMI were better than BMI for predicting 1- and 5-year DR. </p> <p> </p> <p>CONCLUSIONS</p> <p><a>The </a><a>non-linear relationship between</a> muscle mass and BMI may <a>partially contribute to </a><a>BMI limitations in predicting DR</a> after RYGB. </p>