American Diabetes Association
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The Nonlinear Relationship Between Psoas Cross-sectional Area and BMI: A New Observation and Its Insights into Diabetes Remission After Roux-en-Y Gastric Bypass

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posted on 2021-10-13, 21:18 authored by Shaobo Li, Haoyong Yu, Pin Zhang, Yinfang Tu, Yunfeng Xiao, Di Yang, Yuqian Bao, Junfeng Han, Weiping Jia

To explore the potential relevance of muscle mass as a variable contributor to body mass index (BMI) on BMI limitations in predicting diabetes remission (DR) after Roux-en-Y gastric bypass (RYGB).


We evaluated the relationship between muscle mass and BMI in 501 patients with type 2 diabetes mellitus and overweight or obesity. Of which 186 patients who underwent RYGB were studied to determine the role of baseline muscle mass and BMI in predicting DR. Muscle mass was assessed by estimated fat-free mass index (eFFMI) and psoas cross-sectional area (CSA).


A non-linear relationship existed between psoas CSA and BMI, whereas psoas CSA showed a highly positive correlation with eFFMI. Baseline psoas CSA and eFFMI were better than BMI for predicting 1- and 5-year DR.


The non-linear relationship between muscle mass and BMI may partially contribute to BMI limitations in predicting DR after RYGB.


This work was funded by the National Key Research and Development Project of China (grants 2016YFA0502003), the National Natural Sciences Foundation of China (No. 81670791), the Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support (20191920) to Junfeng Han, the Three Year Action Plan for Promoting Clinical Skills and Clinical Innovation in Municipal Hospitals (2020-2022) -Major Clinical Research Projects (SHDC2020CR1017B), and the Innovation Foundation of Translational Medicine of Shanghai Jiao Tong University School of Medicine and Shanghai SJTUSM Biobank. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.