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The Measurement of Insulin Clearance

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posted on 17.07.2020 by Francesca Piccinini, Richard N. Bergman
Insulin clearance has recently been highlighted as a fundamental aspect of glucose metabolism, as it has been hypothesized that its impairment could be related to an increased risk of developing type 2 diabetes. This review focuses on methods used to calculate insulin clearance: from the early surrogate indices employing C-peptide to insulin molar ratio, to direct measurement methods used in animal models, to modeling-based techniques to estimate the components of insulin clearance (hepatic versus extra-hepatic). The methods are explored and interpreted by critically highlighting advantages and limitations.

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R.N.B. is supported by grants from the National Institute of Diabetes and Digestive and Kidney Diseases (DK27619, DK29867), Astra Zeneca and Janssen Research & Development.

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