The Measurement of Insulin Clearance
figureposted on 17.07.2020, 13:46 authored by Francesca Piccinini, Richard N. Bergman
Insulin clearance has recently been highlighted as a fundamental aspect of glucose metabolism, as it has been hypothesized that its impairment could be related to an increased risk of developing type 2 diabetes. This review focuses on methods used to calculate insulin clearance: from the early surrogate indices employing C-peptide to insulin molar ratio, to direct measurement methods used in animal models, to modeling-based techniques to estimate the components of insulin clearance (hepatic versus extra-hepatic). The methods are explored and interpreted by critically highlighting advantages and limitations.