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The Measurement of Insulin Clearance

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posted on 2020-07-17, 13:46 authored by Francesca Piccinini, Richard N. Bergman
Insulin clearance has recently been highlighted as a fundamental aspect of glucose metabolism, as it has been hypothesized that its impairment could be related to an increased risk of developing type 2 diabetes. This review focuses on methods used to calculate insulin clearance: from the early surrogate indices employing C-peptide to insulin molar ratio, to direct measurement methods used in animal models, to modeling-based techniques to estimate the components of insulin clearance (hepatic versus extra-hepatic). The methods are explored and interpreted by critically highlighting advantages and limitations.

Funding

R.N.B. is supported by grants from the National Institute of Diabetes and Digestive and Kidney Diseases (DK27619, DK29867), Astra Zeneca and Janssen Research & Development.

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