The Influence of Maternal Glycemia on Breastmilk Composition and Volume Ingested by Infants of Mothers with Type 1 Diabetes

<p dir="ltr"><b>OBJECTIVES: </b><a href="" target="_blank">Examine relationships between maternal glucose, breastmilk </a><a href="" target="_blank">composition</a> and <a href="" target="_blank">volume ingested by infants of mothers with type 1 diabetes(T1D).</a> To compare breastmilk composition of women with and without T1D.</p><p dir="ltr"><b>RESEARCH DESIGN AND METHODS: </b><a href="" target="_blank">Mid-feed breastmilk samples were collected </a>from 11 mothers with T1D. Maternal continuous glucose monitoring(CGM) data were correlated with breastmilk composition and volume ingested. Breastmilk composition was compared between women with and 5 without T1D.</p><p dir="ltr"><b>RESULTS: </b><a href="" target="_blank">47 breastmilk samples from mothers with T1D were analyzed. Maternal glucose 90-120 minutes before breastfeeding correlated with breastmilk glucose and fructose but not lactose, protein, fatty acids, leptin or volume consumed. Breastmilk leptin correlated with volume of breastmilk consumed (r=0.394 p=0.008). Higher breastmilk glucose (1.0±0.3 versus. 0.7±0.3 mg/ml) and leptin (463.6±480.0 versus 114.4±68.6 pg/mL) were found in women with versus without T1D.</a></p><p dir="ltr"><b>CONCLUSIONS: </b><a href="" target="_blank">Maternal glucose is associated with breastmilk glucose and fructose in women with </a>T1D but not volume of breastmilk consumed.</p>