Supplementary_Table_S1_Final.pdf (207.52 kB)
The Evolution of Hemoglobin A1C Targets for Youth with Type 1 diabetes: Rationale and Supporting Evidence
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posted on 2021-01-11, 09:05 authored by Maria J. Redondo, Ingrid Libman, David M Maahs, Sarah K. Lyons, Mindy Saraco, Jane Reusch, Henry Rodriguez, Linda A. DiMeglioThe
American Diabetes
Association 2020 Standards of Medical Care in Diabetes (Standards of Care) recommends
a hemoglobin A1C of <7% (53 mmol/ml) for many children with type 1 diabetes
(T1D), with an emphasis on target personalization. A higher A1C target of
<7.5% may be more suitable for youth who cannot articulate symptoms of
hypoglycemia or have hypoglycemia unawareness, and for those who do not have
access to analog insulins, advanced diabetes technologies, or cannot monitor
blood glucoses regularly. Even less stringent A1C targets (e.g. <8%) may be warranted
for children with a history of severe hypoglycemia, severe morbidities, or short life
expectancy. During the “honeymoon” period and in situations where lower mean
glycemia is achievable without excessive hypoglycemia or reduced quality of
life, an A1C <6.5% may be safe and effective