American Diabetes Association
Supplementary material dc22-0783.pdf (186.15 kB)

Stress Hyperglycemia Drives the Risk of Hospitalization for Chest Pain in Patients with Ischemia and Non-Obstructive Coronary Arteries (INOCA)

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posted on 2022-12-07, 20:27 authored by Pasquale Mone, Angela Lombardi, Luigi Salemme, Angelo Cioppa, Grigore Popusoi, Fahimeh Varzideh, Antonella Pansini, Stanislovas S. Jankauskas, Imma Forzano, Roberta Avvisato, Xujun Wang, Tullio Tesorio, Gaetano Santulli



Ischemia with non-obstructive coronary arteries (INOCA) is a prevailing finding in patients with angina. However, the main factors underlying the risk of being re-hospitalized for chest pain in patients with INOCA remain mostly unknown.


We evaluated INOCA patients referred to the “Casa di Cura Montevergine”, Mercogliano (Avellino), Italy, since January 2016 to January 2021 for percutaneous coronary intervention (PCI). In these subjects, we assessed the impact of stress hyperglycemia ratio (SHR) on the risk of re-hospitalizations for chest pain.


2874 patients with INOCA successfully completed the study. At 1-year follow-up, the risk of re-hospitalization for chest pain was significantly higher (p<0.001) in INOCA patients with SHR>1, compared to patients with SHR≤1. 

These findings were confirmed by multivariable analyses (adjusting for potential confounders including age, body mass index, blood pressure, heart rate, chronic kidney disease, and cholesterol), propensity score matching, and inverse probability of treatment weighting.


Our data indicate that SHR on hospital admission significantly increases the risk of re-hospitalizations for chest pain in INOCA patients.


U.S. Department of Health and Human Services > National Institutes of Health > National Institute of Diabetes and Digestive and Kidney Diseases R01-DK033823