Supplementary_Table_1_cx01.xlsx (5.59 MB)
Single-Cell Mapping of GLP-1 and GIP Receptor Expression in the Dorsal Vagal Complex
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posted on 2021-06-25, 00:33 authored by Mette Q. Ludwig, Petar V. Todorov, Kristoffer L. Egerod, David P. Olson, Tune H. PersThe dorsal vagal complex
(DVC) in the hindbrain, composed of the area postrema, nucleus of the solitary
tract and dorsal motor nucleus of the vagus, plays a critical role in
modulating satiety. The incretins glucagon-like peptide-1 (GLP-1) and
glucose-dependent insulinotropic polypeptide (GIP) act directly in the brain to
modulate feeding, and receptors for both are expressed in the DVC. Given the
impressive clinical responses to pharmacologic manipulation of incretin
signaling, understanding the central mechanisms by which incretins alter
metabolism and energy balance are of critical importance. Here, we review
recent single-cell approaches used to detect molecular signatures of GLP-1 and
GIP receptor-expressing cells in the DVC. In addition, we discuss how current
advancements in single-cell transcriptomics, epigenetics, spatial
transcriptomics, and circuit mapping techniques have the potential to further
characterize incretin circuits in the hindbrain.