American Diabetes Association
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Rhamnose Displays an Anti-obesity Effect through Stimulating Adipose Dopamine Receptors and Thermogenesis

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posted on 2022-12-06, 19:04 authored by Sihan Lv, Tingting Hu, Ru Zhang, Yue Zhou, Wenjing Yu, Zelin Wang, Changjie Shi, Junjiang Lian, Shichao Huang, Gang Pei, Bing Luan

The imbalance between energy intake and energy expenditure leads to the prevalence of obesity world-widely. Strategy to simultaneously limit energy intake and promote energy expenditure will serve as a powerful mean for new obesity treatment. Here, we identified Rhamnose as a non-nutritive sweetener to promote adipose thermogenesis and energy expenditure. Rhamnose promotes cAMP production and PKA activation through dopamine receptor D1 in adipose tissue. As a result, Rhamnose administration promotes UCP1dependent thermogenesis and ameliorates obesity in mice. Thus, we have demonstrated a Rhamnose-dopamine receptor D1-PKA axis critical for thermogenesis and Rhamnose may serve as a new therapeutic molecular diet against obesity.


This work was supported by grants from National Natural Science Foundation of China (81922015, 82170862, 82171405), Shanghai scientific research project (19ZR1461700), Shuguang Program of Shanghai Education Development Foundation and Shanghai Municipal Education Commission (21SG21), Foundation from the Shanghai Center for Brain Science and Brain-Inspired Technology (#LG-QS-202205-10), and Fundamental Research Funds for the Central Universities.