Retinal Capillary Damage is Already Evident in Patients With Hypertension and Prediabetes and Associated With HbA1c Levels in the Nondiabetic Range
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posted on 2022-03-28, 19:12 authored by Dennis Kannenkeril, Janis M. Nolde, Márcio Galindo Kiuchi, Revathy Carnagarin, Leslie Marisol Lugo-Gavidia, Justine Chan, Anu Joyson, Ancy Jose, Sandi Robinson, Vance B. Matthews, Lakshini Y. Herat, Omar Azzam, Shaun Frost, Markus P. SchlaichObjective:
In a cross-sectional analysis we analyzed whether any change in capillary
density in the retinal circulation could be detected in hypertensive patients
in the pre-diabetic stage.
<p>Methods: In this study, we assessed capillary density
in the foveal (CDF) and parafoveal (CDPF) retinal area using optical coherence
tomography-angiography in 62 hypertensive patients with normal glucose
metabolism and 40 hypertensive patients with prediabetes. </p>
<p>Results: The CDF was lower in patients with prediabetes
compared to patients with normal glucose metabolism. Moreover, we found a correlation between CDF and
HbA1c and glucose levels for the entire cohort. In patients with HbA1c less than 6.5% (48
mmol/mol), CDF was lower in patients with Homeostatic Model Assessment for
Insulin Resistance (HOMA-IR)≥2.5 compared to patients with HOMA-IR<2.5. </p>
<p>Conclusion: Our results demonstrate that hypertensive
patients with prediabetes display retinal capillary changes and that an
association with markers of glucose metabolism exists even within a non-diabetic
HbA1c range. </p>
Funding
No funding.
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