Online-Only_Supplemental_Material.pdf (169.33 kB)
Download file

Retinal Capillary Damage is Already Evident in Patients With Hypertension and Prediabetes and Associated With HbA1c Levels in the Nondiabetic Range

Download (169.33 kB)
figure
posted on 28.03.2022, 19:12 by Dennis Kannenkeril, Janis M. Nolde, Márcio Galindo Kiuchi, Revathy Carnagarin, Leslie Marisol Lugo-Gavidia, Justine Chan, Anu Joyson, Ancy Jose, Sandi Robinson, Vance B. Matthews, Lakshini Y. Herat, Omar Azzam, Shaun Frost, Markus P. Schlaich
Objective: In a cross-sectional analysis we analyzed whether any change in capillary density in the retinal circulation could be detected in hypertensive patients in the pre-diabetic stage.

Methods: In this study, we assessed capillary density in the foveal (CDF) and parafoveal (CDPF) retinal area using optical coherence tomography-angiography in 62 hypertensive patients with normal glucose metabolism and 40 hypertensive patients with prediabetes.

Results: The CDF was lower in patients with prediabetes compared to patients with normal glucose metabolism. Moreover, we found a correlation between CDF and HbA1c and glucose levels for the entire cohort. In patients with HbA1c less than 6.5% (48 mmol/mol), CDF was lower in patients with Homeostatic Model Assessment for Insulin Resistance (HOMA-IR)≥2.5 compared to patients with HOMA-IR<2.5.

Conclusion: Our results demonstrate that hypertensive patients with prediabetes display retinal capillary changes and that an association with markers of glucose metabolism exists even within a non-diabetic HbA1c range.

Funding

No funding.

History