Rapid Changes in Serum Testosterone in Men with Newly Diagnosed Type 2 Diabetes With Intensive Insulin and Metformin
figure
posted on 2021-02-03, 22:09 authored by Yun Hu, Bo Ding, Yun Shen, Reng-Na Yan, Feng-Fei Li, Rui Sun, Ting Jing, Kok-Onn Lee, Jian-Hua MaObjective: To investigate the effect of metformin on
testosterone levels in men with type 2 diabetes mellitus (T2DM).
<p>Methods: Seventy men with newly diagnosed drug naïve T2DM, HbA<sub>1c</sub> >9.0% (75mmol/mol) were treated with intensive insulin pump therapy for 5
days to achieve glucose normalization. They were randomized to control (continued
on intensive insulin only) and metformin (plus metformin) groups (1:1) for one
month. Testosterone was measured at baseline, randomization, and after one-month
treatment. </p>
<p>Results: Total, free and
bioavailable testosterone increased significantly within 5
days (all <i>p</i><0.001). After one
month, compared to controls, the metformin group had lower total (12.7 vs 15.3
nmol/L), free (0.20 vs 0.24 nmol/L), and bioavailable (4.56 vs 5.31 nmol/L)
testosterone (<i>p</i> all <0.05).</p>
<p>Conclusions: In men with T2DM,
one-month oral metformin may decrease serum testosterone levels independent of
blood glucose control. The effects of long-term metformin on testosterone in
men need further study.</p>
Funding
This study was supported by the National Key R&D Program of China (No. 2018YFC1314103), the National Natural Science Foundation of China (No. 81870563) and the Nanjing Municipal Science and Technology Project (No. 201803011).
History
Related Materials
- 1.
- 2.
