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Preparing for the NASH Epidemic: A Call to Action

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posted on 26.07.2021, 13:48 by Fasiha Kanwal, Jay H. Shubrook, Zobair Younossi, Yamini Natarajan, Elisabetta Bugianesi, Mary E. Rinella, Stephen A. Harrison, Christos Mantzoros, Kim Pfotenhauer, Samuel Klein, Robert H. Eckel, Davida Kruger, Hashem El-Serag, Kenneth Cusi
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are common
conditions with a rising burden. Yet, there are significant management gaps between clinical
guidelines and practice in patients with NAFLD and NASH. Further, there is no single global
guiding strategy for the management of NAFLD and NASH. The American Gastroenterological
Association, in collaboration with seven professional associations, convened an international
conference comprising 32 experts in gastroenterology, hepatology, endocrinology, and primary
care providers from the U.S., Europe, Asia, and Australia. Conference content was informed by
the results of a national NASH Needs Assessment Survey. The participants reviewed and
discussed published literature on global burden, screening, risk stratification, diagnosis, and
management of individuals with NAFLD, including those with NASH. Participants identified
promising approaches for clinical practice and prepared a comprehensive, unified strategy for
primary care providers and relevant specialists encompassing the full spectrum of NAFLD/NASH
care. They also identified specific high-yield targets for clinical research and called for a unified,
international public health response to NAFLD and NASH.

Funding

This article is based on a conference sponsored by the American Gastroenterological Association (AGA), with the financial support of independent medical education grants from Intercept Pharmaceuticals, Inc, Pfizer Inc, Allergan, and GENFIT, and the support of the following collaborating medical associations: American Association of Clinical Endocrinologists, American Academy of Family Physicians, American Association for the Study of Liver Diseases, American College of Osteopathic Family Physicians, American Diabetes Association, Endocrine Society, and The Obesity Society.

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