American Diabetes Association
Glucoseintolerance_Supplementary_DC_26July2021.pdf (587.49 kB)

Poor In Utero Growth and Reduced β-Cell Compensation and High Fasting Glucose from Childhood Are Harbingers of Glucose Intolerance in Young Indians

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posted on 2021-10-05, 21:55 authored by Chittaranjan S Yajnik, Souvik Bandopadhyay, Aboli Bhalerao, Dattatray S Bhat, Sanat B Phatak, Rucha H Wagh, Pallavi C Yajnik, Anand Pandit, Sheila Bhave, Kurus Coyaji, Kalyanaraman Kumaran, Clive Osmond, Caroline HD Fall

India is a double world capital for early life undernutrition and type 2 diabetes. We aimed to characterise lifecourse growth and metabolic trajectories in those developing glucose intolerance as young adults, in the Pune Maternal Nutrition Study (PMNS).

Research design and Methods

PMNS is a community-based intergenerational birth cohort established in 1993, with serial information on parents and children through pregnancy, childhood and adolescence. We compared normal glucose tolerant and glucose intolerant participants for serial growth, estimates of insulin sensitivity and secretion (HOMA and dynamic indices) and beta cell compensation accounting for prevailing insulin sensitivity.


At 18 years (N=619) 37% men and 20% women were glucose intolerant (184 prediabetes, 1 diabetes) despite 48% being underweight (BMI<18.5 kg/m2). Glucose intolerant participants had higher fasting glucose from childhood. Mothers of glucose intolerant participants had higher glycemia in pregnancy. Glucose intolerant participants were shorter at birth. Insulin sensitivity decreased with age in all participants, and the glucose intolerant had consistently lower compensatory insulin secretion from childhood. Participants in the highest quintile of fasting glucose at 6 and 12 years had a 2.5- and 4.0-fold higher risk respectively of 18-year glucose intolerance; this finding was replicated in two other cohorts.


Inadequate compensatory insulin secretory response to decreasing insulin sensitivity from early life is the major pathophysiology underlying glucose intolerance in thin rural Indians. Smaller birth size, maternal pregnancy hyperglycemia, and higher glycemia in childhood herald future glucose intolerance, mandating a strategy for diabetes prevention from early life, preferably intergenerationally.


We are grateful to the Indian Council of Medical Research, the Department of Biotechnology, India, the Wellcome Trust and Medical Research Council, UK for their funding support.


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