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Plasma miRNAs and treatment failure among participants in the Treatment Options for Diabetes in Youth (TODAY) study

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posted on 2023-12-28, 17:48 authored by Pandora L Wander, Theo K Bammler, James W. MacDonald, Sengeo Srinouanprachanh, Edward J. Boyko, Daniel A. Enquobahrie

Objective

To identify plasma miRNAs related to treatment failure in youth with type 2 diabetes (T2D).

Research Design & Methods

We examined whether a panel of miRNAs could predict treatment failure in training/test datasets among participants in the Treatment Options for Diabetes in Youth (TODAY) Study (n=209). We also examined whether individual miRNAs were associated with treatment failure.

Results

Participants were 14.5 years old and 62% female. A panel of miRNAs did not predict treatment failure. However, for each doubling, miR-4306 was associated with a 12% decrease and miR-483-3p (p=0.040) was marginally associated with a 12% increase in failure (p=0.080) independent of sex, race/ethnicity, BMI, Tanner stage, HbA1c, maternal diabetes, oral disposition index, and treatment arm. The addition of both miRNAs improved model fit (log likelihood without miRNAs -360.3 vs. with -363.5, p=0.040).

Conclusions

miR-483-3p and miR-4306 may be associated with treatment failure in youth with T2D.

Funding

The project was funded by grants from the National Institutes of Health (K08DK103945, R03DK122100)

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