American Diabetes Association
Browse
4_Online-Only_Supplemental_Material.pdf (651.03 kB)

Plasma Glycated Albumin in Early Pregnancy and Gestational Diabetes Mellitus: a prospective and longitudinal study

Download (651.03 kB)
figure
posted on 2024-07-05, 18:45 authored by Justine Cole, Claire Guivarch, Jing Wu, Paulina Stallcup, Wei Wei Pang, Cuilin Zhang, David B Sacks

Objective

Investigate associations of plasma glycated albumin (GA) concentrations in early and mid-pregnancy with GDM risk.

Research Design and Methods

We measured GA concentrations using blood samples collected at 10-14 and 15-26 weeks’ gestation (GW) in 107 GDM cases and 214 controls from the NICHD Fetal Growth Study. We performed generalized linear mixed-effect regression to test the mean GA difference between GDM cases and controls, and conditional logistic regression to assess prospective associations between GA concentrations and GDM risk.

Results

At 15-26 GW, mean GA was lower in GDM cases than controls (mean (95% CI): 11.90 (6.42-32.76) vs. 12.46 (8.45-38.35), adjusted p-value for difference=0.004). Consistently, women with higher GA concentrations tended to have a lower GDM risk, although the associations were not statistically significant.

Conclusions

This study suggests that GA concentrations in mid-pregnancy might be lower in women who later develop GDM. Further studies are needed to identify the mechanism.

Funding

This work was supported by the Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and National Institutes of Health (Contract Numbers: HHSN275200800013C, HHSN275200800002I, HHSN27500006, HHSN275200800003IC, HHSN275200800014C, HHSN275 200800012C, HHSN275200800028C, and HHSN2752 01000009C. DBS and JC are supported by the Intramural Research Program of the NIH. We thank Asahi Kasei Pharma Corporation (Tokyo, Japan) for providing reagents for the Lucica® GA-L assay.

History

Usage metrics

    Diabetes Care

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC