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Performance of the Dexcom G6 Continuous Glucose Monitoring (CGM) system during cardiac surgery using hypothermic extracorporeal circulation

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posted on 2023-02-21, 17:53 authored by David Herzig, Martina Vettoretti, Dominik P. Guensch, Andreas Melmer, Daniel Schürch, Jonathan Roos, Arna M. C. Goerg, Gabija Krutkyte, Luca Cecchini, Andrea Facchinetti, Andreas P Vogt, Lia Bally

  

Background

Continuous glucose monitoring (CGM) may be challenged by extreme conditions during cardiac surgery using hypothermic extracorporeal circulation (ECC).

Research Design and Methods

We evaluated the Dexcom G6 sensor in 16 subjects undergoing cardiac surgery with hypothermic ECC, of whom 11 received deep hypothermic circulatory arrest (DHCA). Arterial blood glucose, quantified by the Accu-Chek Inform II meter, served as reference. 

Results 

Intra-surgery mean absolute relative difference (MARD) of 256 paired CGM/reference values was 23.8%. MARD was 29.1% during ECC (154 pairs) and 41.6% immediately after DHCA (10 pairs), with a negative bias (signed relative difference: -13.7%, -26.6% and -41.6%). During surgery, 86.3% pairs were in Clarke error grid Zones A or B and 41.0% of sensor readings fulfilled the ISO 15197:2013 norm. Post-surgery, MARD was 15.0%.

Conclusions

Cardiac surgery using hypothermic ECC challenges the accuracy of the Dexcom G6 CGM although recovery appears to occur thereafter. 

Funding

Dexcom

Swiss Foundation of Anaesthesiology and Intensive Care

Swiss Helmut Horten Foundation

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