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Oral Glucose Tolerance Test Predicts Episodic Memory Decline: A 10-Year Population-Based Follow-up Study

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posted on 16.08.2021, 10:46 by Sini Toppala, Laura L. Ekblad, Matti Viitanen, Juha O. Rinne, Antti Jula
Objective: To examine if the 2-hour value of an oral glucose tolerance test (OGTT) can predict cognitive decline.

Research design and methods: This study is based on a subpopulation of the Finnish population-based Health 2000 Survey, and its follow-up, the Health 2011 study. Altogether 961 individuals aged 45–74 (mean 55.6 years, 55.8% women) underwent OGTT in 2001–2002. Categorical verbal fluency, word-list learning, and word-list delayed recall were tested at baseline and at follow-up in 2011. Statistical analyses were performed with multivariable linear models adjusted for previously reported risk factors for cognitive decline.

Results: A higher 2-hour glucose value in the OGTT at baseline predicted worse performance (slope: -0.08, p=0.01) and greater decline (slope: -0.07, p=0.007) in the word-list delayed recall test after 10 years.

Conclusions: Our results indicate that higher 2-hour glucose values in the OGTT predict a decline in episodic memory after 10 years.


S.T. was supported by personal grants from the Betania Foundation, the Uulo Arhio Foundation, the Finnish Medical Foundation, the Juho Vainio Foundation, Turku University Foundation, the Finnish Brain Foundation (Suomen Aivosäätiö sr), and personal fees from Finnish State Research Funding (ERVA). L.L.E. was supported by the Sigrid Juselius Foundation, the Finnish-Norwegian Medical Foundation, the Emil Aaltonen Foundation, and by personal fees from Finnish State Research Funding (ERVA). M.V. was supported by King Gustaf V’s and Queen Victoria’s Freemasons’ Foundation. J.O.R. was supported by grants from the Academy of Finland research grants (#310962 to J.O.R.), the Sigrid Juselius Foundation and Finnish State Research Funding (ERVA).