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Download fileOpposing associations of NT-proBNP with risks of diabetes and diabetes-related complications
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posted on 2020-08-17, 19:14 authored by Anna Birukov, Fabian Eichelmann, Olga Kuxhaus, Elli Polemiti, Andreas Fritsche, Janine Wirth, Heiner Boeing, Cornelia Weikert, Matthias B. SchulzeObjective: Circulating
N-terminal pro b-type natriuretic peptide (NT-proBNP) is a classic diagnostic
and prognostic marker for heart failure. However, it is inversely associated with
diabetes risk. We aimed to investigate relationships of NT-proBNP with risk of
diabetes-related complications in initially healthy individuals.
Results: In multivariable models, NT-proBNP was linearly inversely associated with incident type 2 diabetes, HR (95% CI) per doubling in NT-proBNP: 0.91 (0.86; 0.98). The association was only observable in women, HR (95%CI): 0.80 (0.72; 0.90), compared to 0.98 (0.91; 1.07) in men. Among persons with incident diabetes, NT-proBNP was positively associated with diabetes complications, HR (95% CI): 1.31 (1.13; 1.53) for overall, 1.20 (1.01; 1.43) for micro- and 1.37 (1.03; 1.83) for macrovascular complications.
Conclusions: Although higher NT-proBNP levels are associated with lower diabetes risk, in persons who develop diabetes NT-proBNP is a biomarker for vascular complications independent of potential confounders. Thus, NT-proBNP might be informative to monitor risk for diabetes-related micro- and macrovascular complications, which should be further explored in future prospective studies.
