Mental Health During Late Pregnancy and Postpartum in Mothers With and Without Type 1 Diabetes: The ENDIA Study
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posted on 2022-02-02, 16:34 authored by Madeleine Hall, Helena Oakey, Megan AS Penno, Kelly McGorm, Amanda J Anderson, Pat Ashwood, Peter G Colman, Maria E Craig, Elizabeth A Davis, Mark Harris, Leonard C Harrison, Aveni Haynes, Claire Morbey, Richard O Sinnott, Georgia Soldatos, Peter J Vuillermin, John M Wentworth, Rebecca L Thomson, Jennifer J Couper, the ENDIA Study GroupOBJECTIVE
<p>Pregnancy and type 1 diabetes are each
associated with increased anxiety and depression, but the combined impact on
wellbeing is unresolved. We compared the mental health of women with and
without type 1 diabetes during pregnancy and postpartum, and examined the
relationship between mental health and glycaemic control. </p>
<p>RESEARCH
DESIGN AND METHODS</p>
<p>Participants
were women enrolled from 2016 to 2020 in the Environmental Determinants of
Islet Autoimmunity (ENDIA) study, a pregnancy-birth prospective cohort
following children with a first-degree relative with type 1 diabetes. Edinburgh
Postnatal Depression Scale (EPDS) and Perceived Stress Scale (PSS) were
completed during the third trimester (T3) (median [IQR] 34 [32, 36] weeks) and
postpartum (14 [13, 16] weeks) by 737 women (800 pregnancies) with (n=518) and
without (n=282) type 1 diabetes. </p>
<p>RESULTS
</p>
<p>EPDS
and PSS scores did not differ between women with and without type 1 diabetes
during T3 and postpartum. EPDS scores were
marginally higher in T3: predicted mean (95% CI) 5.7 (5.4, 6.1) than postpartum:
5.3 (5.0, 5.6), independent of type
1 diabetes status (p=0.01). HbA1c levels in type 1 diabetes were 6.3
[5.8, 6.9] % in T3 and did not correlate with EPDS or PSS scores. Reported use
of psychotropic medications was similar in women with (n=44/518 [8%]) and without type 1
diabetes (n=17/282 [6%]), as was
their amount of physical activity.</p>
<p>CONCLUSIONS</p>
<p>Overall,
mental health in late pregnancy and postpartum did not differ between women with
and without type 1 diabetes and mental health scores were not correlated with
glycaemic control. </p>
Funding
Prepared on behalf of the ENDIA Study Team. ANZCTR registration number: ACTRN12613000794707. This research was supported by JDRF Australia, the recipient of the Commonwealth of Australia grant for Accelerated Research under the Medical Research Future Fund, and with funding from the Leona M. and Harry B. Helmsley Charitable Trust (grant key 3-SRA-2020-966-M-N) and The National Health and Medical Research Council of Australia.
History
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