American Diabetes Association
Supplementary_figure_CHO_hybrid_closed_loop_DC_R3-1.pdf (66.56 kB)

Lower Daily Carbohydrate Intake is associated with Improved Glycemic Control in Adults with Type 1 Diabetes using a Hybrid Closed-Loop System

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posted on 2020-09-30, 12:32 authored by Vera Lehmann, Thomas Zueger, Anna Zeder, Sam Scott, Lia Bally, Markus Laimer, Christoph Stettler

To assess the association between daily carbohydrate (CHO) intake and glycemic control in adult hybrid closed-loop (HCL) users with type 1 diabetes mellitus (T1D).

Research Design and Methods

Mean individual daily CHO intake (MIDC) and deviation from MIDC (rMIDC; ≤80% low; 81-120% medium, >120% high CHO consumption) were compared with parameters of glycemic control assessed by continuous glucose monitoring (CGM).


Records from 36 patients (26 male, 10 female; age 36.9±13.5y; HbA1c 7.1±0.9% [54±10mmol/mol]) provided 810 days of data (22.5±6.7 days per patient). Time in range (70-180mg/dL) for low, medium, and high CHO consumption was 77.4±15.4%, 75.2±16.7% and 70.4±17.8%, respectively (p<0.001). Time above range (>180mg/dL) was 20.1±14.7%, 22.0±16.9% and 27.2±18.4%, respectively (p<0.001). There was no between-group difference for time in hypoglycemia (<70mg/dL; p=0.50).


Daily CHO intake was inversely associated with glycemic control in adults with T1D using a HCL system. Lower CHO intake may be a strategy to optimize glucose control in HCL users.


No competing financial interests exist.