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Low Dose IL-2 Combined with Rapamycin Led to an Expansion of CD4+CD25+FOXP3+ Tregs and Prolonged Human Islet-allograft Survival in Humanized Mice

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posted on 07.05.2020 by Ada Admin, Min Hu, Wayne J Hawthorne, Leigh Nicholson, Heather Burns, Yi Wen Qian, David Liuwantara, Elvira Jimenez Vera, Yi Vee Chew, Lindy Williams, Shounan Yi, Karen Keung, Debbie Watson, Natasha Rogers, Stephen I Alexander, Philip J O’Connell

Funding

This work was supported by the National Health and Medical Research Council of Australia (NHMRC), the Juvenile Diabetes Research Foundation/Australian Research Council (JDRF), Diabetes Australia and University of Sydney. M.H was awarded an Early Career Fellowship from the NHMRC (GNT1013185), DVC University of Sydney Research Fellowship (IRMA178768) and Sydney Medical School Early Career Researcher Scheme, and Diabetes Australia Research Program from Diabetes Australia (Y16G-HUMI). N.M.R. is a recipient of a NHMRC Career Devlopment Fellowship (GNT 1158597). P.O.C was a recipient of an Senior Practitioner Fellowship from the NMHRC (GNT1125456) and the principal investigator of JDRF (GNT10373210).

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