American Diabetes Association
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Long-term weight training and mortality in US male health professionals with and without type 2 diabetes

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Version 2 2022-12-02, 17:00
Version 1 2022-11-21, 17:40
posted on 2022-12-02, 17:00 authored by Dong Hoon LeeDong Hoon Lee, Xiao LuoXiao Luo, Leandro F. M. Rezende, Hee-Kyung Joh, NaNa Keum, Eric B. Rimm, Fred K. Tabung, Xuehong Zhang, Edward L Giovannucci


Objective: To investigate the relationship between long-term weight training and mortality in male health professionals with and without type 2 diabetes.

Research Design and Methods: We analyzed 31,140 men without type 2 diabetes (2,588 with type 2 diabetes) from the Health Professionals Follow-up Study (1992-2018). Information on weight training was repeatedly assessed using biennial questionnaires. Cox regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).

Results: During up to 26 years of follow-up, we documented 12,607 deaths (988 deaths among men with type 2 diabetes). Among participants without type 2 diabetes, 1-59 and 60-149 min/week of long-term weight training were associated with 14% (HR=0.86, 95%CI=0.82-0.89) and 8% (HR=0.92, 95%CI=0.85-0.99) lower mortality vs. no weight training, respectively, after adjustment for aerobic activities. However, ≥150 min/week of weight training was not significantly associated with mortality (HR=1.05, 95%CI=0.91-1.20); overall P-trend=0.94, P-quadratic<.001. Meeting recommended aerobic physical activity guideline (≥150 min/week) and any weight training was associated with 20-34% lower mortality. Among participants with type 2 diabetes, moderate level of pre-diagnosis weight training was associated with lower mortality while post-diagnosis weight training showed no association. Performing both weight training and aerobic activities before and after diagnosis was associated with lower mortality.

Conclusions: Moderate level of long-term weight training was associated with lower mortality, independent of aerobic activities among male health professionals with and without type 2 diabetes. Addition of weight training to aerobic activities may provide further benefits for mortality reduction. Studies are needed to confirm our findings in diverse populations.


U.S. Department of Health and Human Services > National Institutes of Health R01 HL35464 U01 CA167552


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