Limitations in Achieving Glycemic Targets from CGM data and Persistence of Severe Hypoglycemia in Adults with Type 1 Diabetes Regardless of Insulin Delivery Method

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posted on 2024-12-19, 17:20 authored by Lori M. Laffel, Jennifer L. Sherr, Jingwen Liu, Wendy A Wolf, Jeoffrey Bispham, Katherine S. Chapman, Daniel Finan, Lina Titievsky, Tina Liu, Kaitlin Hagan, Jason Gaglia, Keval Chandarana, Jeremy Pettus, Richard Bergenstal

Objectives

We captured CGM metrics from a large, online survey of adults with type 1 diabetes to determine how glycemic outcomes varied by insulin delivery form.

Research Design and Methods

Adults with type 1 diabetes from the T1D Exchange Registry/online communities completed the survey and contributed up to 1-year of retrospective CGM data. Self-reported glycemic outcomes and CGM measures were described overall and by insulin delivery method.

Results

The 926 participants completed the survey and provided CGM data. The mean age was 41.9 (standard deviation, 15.7) years and 50.8% reported using automated insulin delivery (AID). While AID users spent more time in range, 27.9% did not achieve time in range targets, 15.5% reported having severe hypoglycemic events (SHEs), and 16.0% had CGM-detected level 2 hypoglycemic events.

Conclusion

Despite use of diabetes technologies, many individuals are unable to achieve glycemic targets and experience severe hypoglycemia, highlighting the need for novel treatments.