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Limitations in Achieving Glycemic Targets from CGM data and Persistence of Severe Hypoglycemia in Adults with Type 1 Diabetes Regardless of Insulin Delivery Method

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posted on 2024-12-19, 17:20 authored by Lori M. Laffel, Jennifer L. Sherr, Jingwen Liu, Wendy A Wolf, Jeoffrey Bispham, Katherine S. Chapman, Daniel Finan, Lina Titievsky, Tina Liu, Kaitlin Hagan, Jason Gaglia, Keval Chandarana, Jeremy Pettus, Richard Bergenstal
<p dir="ltr">Objectives</p><p dir="ltr">We captured CGM metrics from a large, online survey of adults with type 1 diabetes to determine how glycemic outcomes varied by insulin delivery form.</p><p dir="ltr">Research Design and Methods </p><p dir="ltr">Adults with type 1 diabetes from the T1D Exchange Registry/online communities completed the survey and contributed up to 1-year of retrospective CGM data. Self-reported glycemic outcomes and CGM measures were described overall and by insulin delivery method.</p><p dir="ltr">Results</p><p dir="ltr">The 926 participants completed the survey and provided CGM data. The mean age was 41.9 (standard deviation, 15.7) years and 50.8% reported using automated insulin delivery (AID). While AID users spent more time in range, 27.9% did not achieve time in range targets, 15.5% reported having severe hypoglycemic events (SHEs), and 16.0% had CGM-detected level 2 hypoglycemic events.</p><p dir="ltr">Conclusion </p><p dir="ltr">Despite use of diabetes technologies, many individuals are unable to achieve glycemic targets and experience severe hypoglycemia, highlighting the need for novel treatments.</p>

Funding

This study was funded by Vertex Pharmaceuticals Incorporated.

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