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Interrelationships among accumulations of intra- and peri-organ fat, visceral fat, and subcutaneous fat

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posted on 2024-04-24, 17:10 authored by Kento Mitsushio, Megu Y Baden, Takuya Kagisaki, Sarasa Kato, Akiko Niki, Risa Takayama, Tomomi Horii, Harutoshi Ozawa, Chisaki Ishibashi, Yoshiya Hosokawa, Yukari Fujita, Junji Kozawa, Iichiro Shimomura

We aimed to clarify the relationship between intra- and peri-organ fat, visceral fat, and subcutaneous fat. We used abdominal CT to evaluate intra- and peri-organ fat accumulations in the pancreas, liver, spleen, renal parenchyma, renal sinus, and skeletal muscle. The relationships between these fats, visceral fat, and subcutaneous fat were examined by using the partial correlation and covariance analysis, adjusting for BMI. We found that visceral fat and each intra- and peri-organ fat accumulation were positively correlated, whereas subcutaneous fat and the accumulation of each intra- and peri-organ fat and visceral fat were negatively correlated. Pancreas fat, liver fat, renal sinus fat, and skeletal muscle fat accumulated significantly more in people with excessive visceral fat accumulation than in those without excessive visceral fat accumulation (p = 0.01, 0.006, 0.008, 0.02, respectively). In conclusion, intra- and peri-organ fat accumulation in each organ shows a positive correlation with visceral fat and a negative correlation with subcutaneous fat, independent of BMI.

Funding

This study was supported by Grants-in-Aid for Scientific Research [grant number 21K17660]. M.Y.B and H.O belong to the Department of Lifestyle Medicine, which is a sponsored course endowed by KUBARA HONKE Co., Ltd.

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