Impaired awareness of hypoglycemia in type 1 diabetes: A report of an NIDDK Workshop in October 2021

Abstract

Hypoglycemia remains a limiting factor in the optimal treatment of type 1 diabetes (T1D). Repeated episodes of hypoglycemia result in impaired awareness of subsequent hypoglycemic events, inducing a vicious feed-forward cycle and increasing the risk of morbidity and mortality. Why this occurs and how to manage the problem in clinical practice remains uncertain. To address the obstacles and barriers that have hindered the progress in this clinically important area, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) convened a workshop on October 14-15, 2021. This perspective offers a summary of this outstanding meeting that brought clinical and basic scientists from the fields of diabetes, neuroscience, psychology, psychiatry, and imaging together how to consider how to best advance the field of impaired awareness of hypoglycemia and hypoglycemia in general in patients with diabetes.