American Diabetes Association
Demographic_Characteristics_Table-Novel_Communication_paper.pdf (71.99 kB)

Impact of a Novel Diabetes Prevention Intervention for Early Slow Weight Loss Responders among Adults with Prediabetes: An Adaptive Trial

Download (71.99 kB)
posted on 2022-08-30, 18:22 authored by Carla K. Miller, Haikady N. Nagaraja, Jennifer Cheavens, Kentaro Fujita, Sophie Lazarus


Objective: Some people are slower to respond during lifestyle interventions. An adaptive “rescue” intervention may improve outcomes among slow responders. The impact of a worksite “rescue” intervention for early slow responders was evaluated.

Research Design and Methods: Employees ≥ 21 years old with prediabetes were stratified to intervention using a 2.5% weight loss (%WL) threshold at week 5. Outcomes were assessed at baseline and 4-months using mixed effect and linear regression models.

Results: Significant improvement occurred in mean %WL, glycemia, total cholesterol, and triglycerides in the standard compared to adaptive (GLB+) intervention (all P ≤ 0.01). However, GLB+ also experienced significant reduction in %WL and glycemia (all P < 0.01). %WL at week 5 significantly predicted %WL at 4-months (P < 0.0001). Between-group difference of 4-month %WL was not significant for someone achieving 2.5%WL at week 5.

Conclusions: Diabetes prevention programs should consider weight loss success following one month of treatment and offer a “rescue” intervention to early slow weight loss responders. 


Research reported in this publication was supported by the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under award number R01DK112930 and by award number UL1TR002733 from the National Center for Advancing Translational Sciences. The content is solely the responsibility of the authors and does not necessarily represent the official view of the National Center for Advancing Translational Sciences or the National Institutes of Health.


Usage metrics

    Diabetes Care


    Ref. manager