American Diabetes Association
Boucsein_A_et_al_AHCL_In_High-Risk_Youth_Supplemental_Material_Revision.pdf (178.88 kB)
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Impact of Advanced Hybrid Closed-Loop on Youth with High-Risk Type 1 Diabetes Using Multiple Daily Injections

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posted on 2023-01-23, 19:03 authored by Alisa Boucsein, Antony S. Watson, Carla M Frewen, Olivia J. Sanders, Jillian J. Haszard, Shirley D. Jones, Philippa J. Milford-Hughes, Martin I. de Bock, Benjamin J. Wheeler


Objective: To evaluate glycemic outcomes in youth (aged 13–25 years) with type 1 diabetes and high-risk glycemic control [HbA1c ≥ 8.5% (69 mmol/mol)] on multiple daily injections (MDI) after transitioning to advanced hybrid closed-loop (AHCL) therapy. 

Research Design and Methods: This prospective 3-month single-arm, dual-center study enrolled 20 participants, and all completed the study. 

Results: HbA1c decreased from 10.5 ± 2.1% (91.2 ± 22.8 mmol/mol) at baseline to 7.6 ± 1.1% (59.7 ± 11.9 mmol/mol) and time spent in target range 70–180 mg/dL (3.9–10.0 mmol/L) increased from 27.6 ± 13.2% at baseline, to 66.5 ± 9.8% after 3 months of AHCL. Two episodes of diabetic ketoacidosis attributed to infusion set failure occurred. 

Conclusions: AHCL has the potential to improve suboptimal glycemia in youth with type 1 diabetes previously on MDI.


This study was funded by a Lottery Health Research Grant (LHR-2021-153881).