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Identifying Potential Intervention Points for Acute Hypoglycemic Events in Patients With Type 2 Diabetes Using Retrospective Clinical Data

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posted on 01.03.2021, 17:41 by Mary E. Lacy, Rachel A. Whitmer, Sei J. Lee, Robert J. Rushakoff, Mark J. Pletcher
This retrospective study examined changes in medication orders as a risk factor for future acute hypoglycemic events. The investigators identified factors associated with acute hypoglycemic events resulting in emergency department visits or inpatient admissions. Non-Hispanic Black race, chronic kidney disease, insulin at baseline, and non-private insurance were associated with higher risk of an acute hypoglycemic event, whereas age, sex, and A1C were not. After adjustment for other risk factors, changes in insulin orders after A1C measurement were associated with a 1.5 times higher risk of an acute hypoglycemia (adjusted hazard ratio 1.48, 95% CI 1.08–2.03). These results further understanding of risk factors and clinical processes relevant to predicting and preventing acute hypoglycemia.

Funding

U.S. Department of Health and Human Services > National Institutes of Health > National Center for Advancing Translational Sciences KL2TR001996

U.S. Department of Health and Human Services > National Institutes of Health > National Institute on Aging R01 AG047500 R01AG047897 R01AG057751 T32 AG049663

Patient-Centered Outcomes Research Institute PPRN-1306-04709

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