Online-Only_Supplemental_Material-1.pdf (268.05 kB)

Hyperglycemia at hospital admission is associated with severity of the prognosis in patients hospitalized for COVID-19: The Pisa COVID-19 Study

Download (268.05 kB)
figure
posted on 18.09.2020 by Alberto Coppelli, Rosa Giannarelli, Michele Aragona, Giuseppe Penno, Marco Falcone, Giusy Tiseo, Lorenzo Ghiadoni, Greta Barbieri, Fabio Monzani, Agostino Virdis, Francesco Menichetti, Stefano Del Prato, Pisa-COVID-19 Study Group
OBJECTIVE

To explore whether at-admission hyperglycemia is associated with worse outcomes in patients hospitalized for Covid-19.

RESEARCH DESIGN AND METHODS

Hospitalized Covid-19 subjects (N=271) were subdivided based on at-admission glycemic status: 1. glucose levels <7.78 mmol/L (NG; N=149; 55.0%; median glucose 5.99 [5.38-6.72] mmol/L), 2. known diabetes (DM; N=56; 20.7%; 9.18 [7.67-12.71] mmol/L), and 3. no diabetes and glucose levels ≥7.78 mmol/L (HG; N=66, 24.3%; 8.57 [8.18-10.47] mmol/L).

RESULTS

Neutrophils were higher and lymphocytes and PaO2/FiO2 lower in HG than DM and NG. DM and HG had higher D-Dimer and worse inflammatory profile. Mortality was greater in HG (39.4% vs 16.8%; unadjusted HR 2.20, 95%CI 1.27-3.81, p=0.005) than in NG (16.8%), and marginally so in DM (28.6%; HR 1.73, 0.92-3.25, p=0.086). Upon multiple adjustments, only HG remained an independent predictor (1.80, 1.03-3.15, p=0.04). After stratification by quintile of glucose levels, mortality was higher in Q4 (HR 3.57, 1.46-8.76, p=0.005) and marginally in Q5 (29.6%; HR 2.32, 95% CI 0.91-5.96, p=0.079) vs Q1.

CONCLUSIONS

Hyperglycemia is an independent factor associated with severe prognosis in people hospitalized for COVID-19.

Funding

This work was supported by research grant Punteggio Rating of the University of Pisa.

History

Exports

Logo branding

Exports