American Diabetes Association
R3_Online-only_Supplemental_material.pdf (1.24 MB)

High mannose correlates with surrogate indexes of insulin resistance and is associated with an increased risk of cardiovascular events independently of glycaemic status and traditional risk factors

Download (1.24 MB)
posted on 2023-12-06, 21:12 authored by Elena Fortin, Beatrice Campi, Ele Ferrannini, Andrea Mari, Linda G. Mellbin, Anna Norhammar, Per Näsman, Lars Rydén, Alessandro Saba, Giulia Ferrannini

Objective: To explore the associations between mannose, indexes of insulin resistance (IR) and secretion and long-term cardiovascular outcomes.

Research Design and Methods: Fasting mannose was assayed in 1403 participants, half of which had a first myocardial infarction (MI), with either normal glucose tolerance (n=1045) or newly detected dysglycaemia (i.e., impaired glucose tolerance or type 2 diabetes; n=358). Regression models were used to explore mannose associations with surrogate indexes of IR/insulin secretion. Multivariate Cox models were used to investigate the independent association between “high” (higher quartile) vs. “low” (lower three quartiles) mannose and major adverse cardiac events (MACE, N=163) during 10-year follow-up.

Results: Mannose was independentely associated with IR indexes (all p≤0.001). High vs. low mannose was independentely associated with MACE (hazard ratio: 1.54, 95% confidence interval 1.07-2.20) in the overall population.

Conclusions: Mannose might represent a new biomarker able to track early, potentially detrimental glucometabolic alterations, independently of glycaemic state.


The PAROKRANK study was academy-driven and was supported by grants from AFA Insurance Foundation, the Swedish Heart-Lung Foundation, the Swedish Research Council, Eklund Foundation and the Swedish Society of Medicine and the Stockholm County Council (ALF project and Steering committee KI/SLL for odontological research).


Usage metrics

    Diabetes Care


    Ref. manager