Homer_et_al_2020_Supplementary_Tables_V4_clean.pdf (224.35 kB)

Frequency of Interruptions to Sitting Time: Benefits for Postprandial Metabolism in Type 2 Diabetes

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posted on 26.04.2021, 21:16 by Ashleigh R. Homer, Frances C. Taylor, Paddy C. Dempsey, Michael J. Wheeler, Parneet Sethi, Melanie K. Townsend, Megan S. Grace, Daniel J. Green, Neale D. Cohen, Robyn N. Larsen, Bronwyn A. Kingwell, Neville Owen, David W. Dunstan
Purpose: To determine whether interrupting sitting with brief bouts of simple resistance activities (SRAs) at different frequencies improves postprandial glucose, insulin and triglycerides in adults with medication-controlled type 2 diabetes (T2D).

Methods: Participants [n=23, 10 females, Age: 62±8 y (mean±SD), BMI: 32.7 ± 3.5 kg.m-2] completed a three-armed randomized crossover trial (6-14 day washout): sitting uninterrupted for 7 h (SIT); sitting with 3-minute SRAs (half-squats, calf raises, gluteal contractions, and knee raises) every 30 minutes (SRA3); and, sitting with 6-minute SRAs every 60 minutes (SRA6). Net incremental areas under the curve (iAUCnet) for glucose, insulin, and triglycerides were compared between conditions.

Results: Glucose and insulin 7 h iAUCnet were attenuated significantly during SRA6 (glucose 17.0 mmol.h.L-1, 95% CI 12.5, 21.4; insulin 1229 pmol.h.L-1, 95% CI 982, 1538) when compared to SIT (glucose 21.4 mmol.h.L-1, 95% CI 16.9, 25.8; insulin 1411 pmol.h.L-1, 95% CI 1128, 1767; P < 0.05), and compared to SRA3 ( for glucose only; 22.1 mmol.h.L-1, 95% CI 17.7, 26.6; P = 0.01) No significant differences in glucose or insulin iAUCnet were observed comparing SRA3 and SIT. There was no statistically significant effect of condition on triglyceride iAUCnet.

Conclusion: In adults with medication-controlled T2D, interrupting prolonged sitting with 6-minute SRAs every 60 minutes reduced postprandial glucose and insulin responses. Other frequencies of interruptions and potential longer-term benefits require examination to clarify clinical relevance.


This research was supported by a Heart Foundation Vanguard Grant (Award no. 101449), a NHMRC Centre of Research Excellence grant #1057608, and the Victorian Government OIS scheme. A.R.H. and F.C.T are supported by Research Training Program (RTP) Awards. P.C.D., D.J.G., N.O., B.A.K., and D.W.D. are supported by the NHMRC Fellowships scheme.