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Elevated First-Trimester Neutrophil Count Is Closely Associated with the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes

posted on 20.04.2020, 22:55 by Ada Admin, Tiange Sun, Fanhua Meng, Hongmei Zhao, Min Yang, Rui Zhang, Zhiyan Yu, Xinmei Huang, Heyuan Ding, Jun Liu, Shufei Zang
Chronic low-grade inflammation plays a central role in the pathophysiology of gestational diabetes mellitus (GDM). In order to investigate the ability of different inflammatory blood cell parameters in predicting the development of GDM and pregnancy outcomes, 258 women with GDM and 1154 women without were included in this retrospective study. First-trimester neutrophil count outperformed white blood cell (WBC) count, and neutrophil-to-lymphocyte ratio (NLR) in the predictability for GDM. Subjects were grouped based on tertiles of neutrophil count during their first-trimester pregnancy. The results showed that as the neutrophil count increased, there was a step-wise increase in GDM incidence, as well as glucose and glycosylated hemoglobin (HbA1c) level, Homeostasis Model Assessment for Insulin Resistance (HOMA-IR), macrosomia incidence and newborn weight. Neutrophil count was positively associated with pre-pregnancy Body Mass Index (BMI), HOMA-IR and newborn weight. Additionally, neutrophil count was an independent risk factor for the development of GDM, regardless of the history of GDM. Spline regression showed that there was a significant linear association between GDM incidence and continuous neutrophil count when it exceeded 5.0 × 109/L. This work suggested that first-trimester neutrophil count is closely associated with the development of GDM and adverse pregnancy outcomes.


Natural Science Foundation of China (81700510) Medical Key Faculty Foundation of Shanghai(ZK2019B15) Health Profession Clinical Funds of Shanghai Municipal Health Commission (201940295) Science Foundation of Fifth People's Hospital of Shanghai (2019WYZD02, 2018WYZD04) The Science and Technology Planning Project of Hangzhou City (20170533B43)