American Diabetes Association
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Effect of SARS-CoV-2 Infection and Infection Severity on Longer-Term Glycemic Control and Weight in People With Type 2 Diabetes

posted on 2022-09-13, 14:10 authored by Rachel Wong, Rohith Vaddavalli, Margaret A. Hall, Monil V. Patel, Carolyn T. Bramante, Elena Casarighi, Steven G. Johnson, Veena Lingam, Joshua D. Miller, Jane Reusch, Mary Saltz, Til Stürmer, Jena S. Tronieri, Kenneth J. Wilkins, John B. Buse, Joel Saltz, Jared D. Huling, Richard Moffitt, N3C Consortium


Objective: To evaluate the association between COVID-19 infection and severity of infection on longer-term glycemic control and weight in persons with type 2 diabetes mellitus (T2D) in the U.S.

Research Design and Methods: We conducted a retrospective cohort study using longitudinal electronic health record data of patients with COVID-19 infection from the National COVID Cohort Collaborative (N3C). Patients were ≥18 years old with an ICD-10 diagnosis of T2D and at least 1 HbA1c and weight measurement prior to and after an index date of their first COVID-19 diagnosis or negative SARS-CoV-2 test. We used propensity scores to identify a matched cohort balanced on demographic characteristics, comorbidities, and medications used to treat diabetes. The primary outcome was the post-index average hemoglobin A1c (HbA1c) and post-index average weight over a 1-year time period beginning 90 days after the index date among patients who did and did not have COVID-19 infection. Secondary outcomes were post-index average HbA1c and weight in patients who required hospitalization or mechanical ventilation.

Results: There was no significant difference in the post-index average HbA1c or weight in patients who had COVID-19 infection compared to controls. Mechanical ventilation was associated with a decrease in average HbA1c after COVID-19 infection.

Conclusions: In a multicenter cohort of patients in the U.S. with pre-existing T2D, there was no significant change in longer-term average HbA1c or weight among patients who had COVID-19 infection. For patients with COVID-19 infection, mechanical ventilation was associated with a decrease in HbA1c after infection.


This work was supported by NCATS U24 TR002306 (MAH, RV, RW, RM). JST was supported, in part, by a Mentored Patient Oriented Research Award (K23DK116935) from the National Institutes of Health/National Institute of Diabetes, Digestive, and Kidney Disease. JBB was supported in part by grants from the National Institutes of Health (UL1TR002489, P30DK124723).


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