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dc22-1018 Online_supplement_DC22-1018.pdf (3.19 MB)

Dietary factors and all-cause mortality in individuals with type 2 diabetes: a systematic review and meta-analysis of prospective observational studies

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posted on 2023-01-26, 00:10 authored by Janett Barbaresko, Alexander Lang, Edyta Szczerba, Christina Baechle, Julia Beckhaus, Lukas Schwingshackl, Manuela Neuenschwander, Sabrina Schlesinger

   

Background: Type 2 diabetes is a major health concern associated with mortality. Diet may influence the progression of diabetes; however, systematic reviews are lacking.

Purpose: To systematically summarise the evidence on diet and all-cause mortality in individuals with type 2 diabetes.

Data sources: PubMed and Web of Science were searched until June 2022. 

Study selection: Prospective observational studies investigating dietary factors in association with all-cause mortality in individuals with type 2 diabetes. 

Data synthesis: We identified 107 studies. Moderate certainty of evidence was found for inverse associations of higher intakes of fish (SRR per serving/week: 0.95; 95% CI: 0.92, 0.99; n=6 studies), whole grain (per 20 g/d: 0.84; 95% CI: 0.71, 0.99; n=2), fibre (per 5 g/d: 0.86; 95% CI: 0.81, 0.91; n=3) and n-3 polyunsaturated fatty acids (per 0.1 g/d: 0.87; 95% CI: 0.82, 0.92; n=2) and mortality. There was low certainty of evidence for inverse associations of vegetable consumption ( per 100 g/d: 0.88; 95% CI: 0.82, 0.94; n=2), plant protein (per 10 g/d: 0.91; 95% CI: 0.87, 0.96; n=3), and for positive associations of egg consumption (per 10 g/d: 1.05; 95% CI: 1.03, 1.08, n=7), and cholesterol intake (per 300 mg/d: 1.19; 95% CI: 1.13, 1.26; n=2). For other dietary factors, evidence was uncertain or no association was observed.

Conclusion: 

Higher intake of fish, whole grain, fibre and n-3 polyunsaturated fatty acids were associated with all-cause mortality in individuals with type 2 diabetes. There is limited evidence for other dietary factors and thus, more research is needed.  

Funding

Federal Ministry of Education and Research

Federal Ministry of Health

Ministry of Science and Culture of the State North Rhine-Westphalia

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