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DC22-0853 Appendix_1_ADDN_Study_Group.pdf (44.15 kB)

Diabetic Ketoacidosis at Onset of Type 1 Diabetes and Long-term HbA1c in 7,961 Children and Young Adults in the Australasian Diabetes Data Network

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Version 2 2022-12-01, 21:00
Version 1 2022-12-01, 20:58
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posted on 2022-12-01, 21:00 authored by Helen F Clapin, Arul Earnest, Peter G Colman, Elizabeth A Davis, Craig Jefferies, Kym Anderson, Melissa Chee, Philip Bergmann, Martin de Bock, Kung-Ting KaoKung-Ting Kao, P Gerry Fegan, D Jane Holmes-Walker, Stephanie Johnson, Bruce R King, Meng Tuck MokMeng Tuck Mok, Kruthika Narayan, Alexia S Peña Vargas, RICHARD SINNOTTRICHARD SINNOTT, Benjamin J Wheeler, Anthony ZimmermannAnthony Zimmermann, Maria E. Craig, Jenny J Couper, the ADDN Study group

  

Abstract 

OBJECTIVE 

The relationship between diabetic ketoacidosis (DKA) at diagnosis of type 1 diabetes and long-term glycemic control varies between studies. We aimed firstly to characterise the association of DKA and its severity with long-term HbA1c in a large contemporary cohort, and secondly to identify other independent determinants of long-term HbA1c. 

RESEARCH DESIGN AND METHODS 

Participants were 7961 children and young adults diagnosed with type 1 diabetes by age 30 years from 2000-2019 and followed prospectively in the Australasian Diabetes Data Network (ADDN) until 31/12/2020. Linear mixed effect models related variables to HbA1c. 

RESULTS 

DKA at diagnosis was present in 2647 (33.2%) participants. Over a median 5.6 (IQR 3.2,9.4) years follow-up, participants with severe, but not moderate or mild, DKA at diagnosis had a higher mean HbA1c (+0.23%, 95% CI:0.11,0.28; [+2.5mmol/mol, 95% CI:1.4,3.6]; p<0.001) compared to those without DKA. Use of continuous subcutaneous insulin infusion (CSII) was independently associated with a lower HbA1c (-0.28%, 95% CI:-0.31,-0.25; [-3.1mmol/mol, 95% CI:-3.4,-2.8]; p<0.001) than multiple daily injections, and CSII use interacted with severe DKA to lower predicted HbA1c. Indigenous status was associated with higher HbA1c (+1.37%, 95% CI:1.15,1.59; [+15.0mmol/mol, 95% CI:12.6,17.4]; p<0.001), as was residing in postcodes of lower socioeconomic status (most versus least disadvantaged quintile +0.43%, 95% CI:0.34,0.52; [+4.7mmol/mol, 95% CI:3.4,5.6]; p<0.001). 

CONCLUSIONS 

Severe, but not mild or moderate, DKA at diagnosis was associated with a marginally higher HbA1c over time, an effect which was modified by use of CSII. Indigenous status and lower socioeconomic status were independently associated with higher long-term HbA1c.

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