PRESENTATION
DOCUMENT
1/1
Depletion of adipocyte Becn1 leads to lipodystrophy and metabolic dysregulation
figure
posted on 2020-12-11, 17:23 authored by Ada AdminAda Admin, Young Jin, Yul Ji, Yaechan Song, Sung Sik Choe, Yong Geun Jeon, Heeju Na, Tae Wook Nam, Hye Jeong Kim, Hahn Nahmgoong, Sung Min Kim, Jae-woo Kim, Ki Taek Nam, Je Kyung Seong, Daehee Hwang, Chan Bae Park, In Hye Lee, Jae Bum Kim, Han-Woong LeeBecn1/Beclin-1 is a core component
of the
class III phosphatidylinositol 3-kinase required for autophagosome formation and vesicular trafficking. Although
Becn1 has been implicated in numerous
diseases such as cancer, aging, and neurodegenerative disease, the role of Becn1 in white adipose tissue and
related metabolic diseases remains elusive. Here we show that adipocyte-specific
Becn1 knockout mice develop severe
lipodystrophy, leading to adipose tissue inflammation, hepatic steatosis,
insulin resistance. Ablation of Becn1
in adipocytes stimulates programmed cell death in a cell-autonomous
manner, accompanied by elevated ER stress gene
expression. Furthermore, we observed that Becn1
depletion sensitized mature adipocytes to ER stress, leading to accelerated
cell death. Taken together, these data suggest that adipocyte Becn1 would serve as a crucial player
for adipocyte survival and adipose tissue homeostasis.