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Comparing IADPSG and NICE diagnostic criteria for GDM in predicting adverse pregnancy outcomes

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posted on 26.07.2022, 12:10 authored by Yuanying He, Ronald Ching-Wan Ma, H. David McIntyre, David A. Sacks, Julia Lowe, Patrick M. Catalano, Wing Hung Tam


Objective: To compare the performance of diagnostic criteria for gestational diabetes mellitus (GDM) proposed by the International Association of the Diabetes and Pregnancy Study Groups (IADPSG) with those endorsed by the National Institute for Health and Care Excellence (NICE) in predicting adverse pregnancy outcomes.

Research Design and Methods: We performed a secondary data analysis on the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study participants in five study centers. Logistic regression analyses were performed and Akaike information criterion were applied for the comparison of different statistical prediction models. We further analyzed the performance by four ethnic subgroups, namely, Whites, Hispanics, Asians and Blacks.

Results: Among all, IADPSG criteria diagnosed 267 (4.1%) more women with GDM, but predicted primary caesarean section (CS), large for gestation (LGA) and neonatal adiposity better than did NICE criteria after adjustment for potential confounders. Among Whites, IADPSG criteria diagnosed 65 (2.5%) more subjects with GDM, and predicted LGA and neonatal adiposity better, but predicted hypertensive disorders, primary CS and clinical neonatal hypoglycemia worse. Among Hispanics, the IADPSG criteria diagnosed 203 (12.1%) more with GDM but performed better in predicting hypertensive disorders, LGA, neonatal adiposity and hyperinsulinemia. Among Asians, the IADPSG criteria diagnosed 34 (2.0%) fewer subjects with GDM but predicted hypertensive disorders better in the unadjusted model. In Blacks, IADPSG criteria diagnosed 34 (10.5%) more women with GDM.

Conclusion: IADPSG criteria appear to be more favorable than NICE for identification of adverse pregnancy outcomes among Hispanic and Asian women, while it is comparable to NICE among the Whites.



The HAPO study was funded by the National Institute of Child Health and Human Development (grant no. R01-HD34242) and the National Institute of Diabetes and Digestive and Kidney Diseases (grant no. R01-HD34243). The current secondary analysis was funded by the Lee Hysan Foundation Research Grant and Endowment Fund Research Grant Schemes 2020-2021.