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Association of Serum 25-Hydroxyvitamin D With Cardiovascular Outcomes and All-Cause Mortality in Individuals With Prediabetes and Diabetes: Results From the UK Biobank Prospective Cohort Study

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posted on 2022-02-28, 20:15 authored by Peizhen Zhang, Dan Guo, Bingyan Xu, Chensihan Huang, Shunyu Yang, Weiwei Wang, Wenhui Liu, Yajuan Deng, Kangli Li, Deying Liu, Jiayang Lin, Xueyun Wei, Yan Huang, Huijie Zhang

To examine the associations of circulating 25-hydroxyvitamin D (25(OH)D) concentrations with CVD and all-cause mortality in individuals with prediabetes and diabetes from the large population-based UK Biobank cohort study.


A total of 67 789 individuals diagnosed with prediabetes and 24 311 with diabetes who had no CVD or cancer at baseline were included in the current study. Serum 25(OH)D concentrations was measured at baseline. The Cox proportional hazard models were used to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) for cardiovascular outcomes and mortality after 10-14 years.


After multivariable adjustment, higher serum 25(OH)D levels were significantly and nonlinearly associated with lower risk of cardiovascular outcomes and all-cause mortality among participants with prediabetes and diabetes (all P non-linearity < 0.05). Compared with those in the lowest category of 25(OH)D levels (<25 nmol/L), participants with prediabetes in the highest category of 25(OH)D levels (≥75 nmol/L) were significantly associated with lower risk of cardiovascular events (HR, 0.78; 95% CI, 0.71-0.86), coronary heart disease (CHD) (HR, 0.79; 95% CI, 0.71-0.89), heart failure (HR, 0.66; 95% CI, 0.54-0.81), stroke (HR, 0.75; 95% CI, 0.61-0.93), CVD mortality (HR, 0.43; 95% CI, 0.32-0.59), and all-cause mortality (HR, 0.66; 95%CI, 0.58-0.75). Likewise, these associations with cardiovascular events, CHD, heart failure, CVD mortality, and all-cause mortality were observed among participants with diabetes except for stroke.


These findings highlight the importance of monitoring and correcting vitamin D deficiency in the prevention of CVD and mortality among adults with prediabetes and diabetes.


This study was supported by the National Key Research and Development Project (No.2018YFA0800404), National Natural Science Foundation of China (No. 81970736), and Key-Area Clinical Research Program of Southern Medical University (No.LC2019ZD010 and 2019CR022). Dr. Huijie Zhang was partially supported by Outstanding Youths Development Scheme of Nanfang Hospital, Southern Medical University (No.2017J005).