Online Appendix.pdf (719.82 kB)
Alteration of Individual Metabolic Network of Brain Based on Jensen-Shannon Divergence Similarity Estimation in the Elderly with Type 2 Diabetes Mellitus
figure
posted on 2022-02-28, 22:27 authored by Yu-Lin Li, Jia-Jia Wu, Jie Ma, Si-Si Li, Xin Xue, Dong Wei, Chun-Lei Shan, Xu-Yun Hua, Mou-Xiong Zheng, Jian-Guang XuThe present
study aimed to investigate the interactive effect between aging and type 2
diabetes mellitus (T2DM) on brain glucose metabolism, individual metabolic
connectivity and network properties. A 2 × 2 factorial-designed study was
conducted, 83 T2DM patients (40 elderly and 43 middle-aged) and 69
gender-matched HCs (34 elderly and 35 middle-aged) underwent an 18F fluorodeoxyglucose-positron
emission tomography/magnetic resonance (18F-FDG PET/MR) scanning. The
Jensen-Shannon Divergence was applied to construct individual metabolic
connectivity and network. The topological properties of network were quantified
with graph theoretical analysis. The general linear model (GLM) was used to mainly
estimate the interaction effect between aging and T2DM on glucose metabolism,
metabolic connectivity and network. There was an interaction effect between
aging and T2DM on glucose metabolism, metabolic connectivity and regional
metabolic network properties (all P < 0.05). The post-hoc analyses
showed that compared with the elderly HCs and middle-aged with T2DM groups, elderly
T2DM group had decreased glucose metabolism, increased metabolic connectivity
and regional metabolic network properties in cognition-related brain regions
(all P < 0.05). The age and fasting plasma glucose had negative
correlations with glucose metabolism, and positive correlations with metabolic
connectivity. The elderly with T2DM had glucose hypometabolism,
strengthened functional integration and increased efficiency of information
communication mainly located in cognition-related
brain regions, above metabolic connectivity patterns changes might be
compensatory changes for glucose hypometabolism.