DC20-0171-R2-Suput-Acute-hyperglycemia-spatial-WM-Online-only-Suppl-Apr-9-2020.docx (152.02 kB)

Acute hyperglycemia and spatial working memory in adolescents with type 1 diabetes

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posted on 29.05.2020, 22:33 by Jasna Šuput Omladič, Anka Slana Ozimič, Andrej Vovk, Dušan Šuput, Grega Repovš, Klemen Dovc, Nataša Bratina, Magdalena Avbelj Stefanija, Tadej Battelino
Objective: To investigate the effect of acute hyperglycemia on brain function in adolescents with type 1 diabetes.

Research Design and Methods: Twenty participants with type 1 diabetes (T1D) (age 14.64 ±1.78 years) and 20 age-matched healthy controls (age 14.40± 2.82 years) performed two functional magnetic resonance imaging sessions. Participants with T1D performed the first scanning session under euglycemic and the second under hyperglycemic clamp (20 mmol/L (360 mg/dL)).

Results: Lower spatial working memory (sWM) capacity during acute hyperglycemia and significant differences in activation of regions of interest during different stages of the spatial working memory task (p=0.014) were observed.

Conclusions: Acute hyperglycemia negatively affected sWM capacity in adolescents with T1D, which is relevant for daily functioning and academic performance.


The study was supported in part by the Slovenian Research Agency grants # P3-0019, P3-0343, J7-9411, J7-1820 and University Medical Center Ljubljana Research grants 20180032 and 20190185. Funding sources were not involved in the collection, analysis, or interpretation of any data; in the writing of the report; or in the decision to submit the article for publication.