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Download fileActive cigarette smoking is associated with an exacerbation of genetic susceptibility to diabetes
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posted on 2020-10-01, 18:36 authored by Ada AdminAda Admin, Wan-Yu Lin, Yu-Li Liu, Albert C. Yang, Shih-Jen Tsai, Po-Hsiu KuoThe heritability levels of two traits for diabetes
diagnosis, fasting serum glucose (FG) and
glycated hemoglobin (HbA1c), were estimated to be 51% ~ 62%. Studies have shown that cigarette
smoking is a modifiable risk factor for diabetes. It is important to uncover whether smoking may
modify the genetic risk of diabetes. This study included a discovery cohort (TWB1)
of 25,460 and a replication cohort (TWB2) of 58,774 unrelated Taiwan Biobank
subjects. Genetic risk score (GRS)
of each TWB2 subject was calculated with weights retrieved from TWB1 analyses.
We then assessed the significance of GRS-smoking interactions on FG/HbA1c/diabetes
while adjusting for covariates.
A total of 5 smoking measurements were investigated respectively, including
“active smoking status”, “pack-years”, “years as a smoker”, “packs smoked per
day”, and “hours as a passive smoker per week”. Except passive smoking, all
smoking measurements were associated with FG/HbA1c/diabetes (P < 0.0033)
and were associated with an exacerbation of the genetic risk of FG/HbA1c (
< 0.0033). For example, each 1 standard
deviation increase in GRS is associated
with a 1.68% higher FG in subjects consuming one more pack of cigarettes per
day (
).
Smoking cessation is especially
important for people who are more genetically predisposed to diabetes.