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Abdominal obesity genetic variants predict waist circumference regain after weight loss

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posted on 2023-07-26, 19:39 authored by Malene Revsbech CHRISTIANSEN, Tuomas O. KILPELÄINEN, Jeanne M. MCCAFFERY

While many individuals are able to achieve weight loss, maintaining this loss over time is challenging. We aimed to study whether genetic predisposition to general or abdominal obesity predicts weight re-gain after weight loss. We examined the associations between genetic risk scores for higher BMI and higher waist-hip ratio adjusted for BMI (WHRadjBMI) with changes in weight and waist circumference up to 3 years following one year of a weight loss program in participants (822 women, 593 men) from the Look AHEAD study who had lost ≥ 3% of their initial weight. Genetic predisposition to higher BMI or WHRadjBMI was not associated with weight regain after weight loss. However, the WHRadjBMI genetic score did predict an increase in waist circumference, independent of weight change. To conclude, a genetic predisposition to higher WHRadjBMI predicts an increase in abdominal obesity after weight loss, whereas genetic predisposition to higher BMI is not predictive of weight regain. These results suggest that genetic effects on abdominal obesity may be more pronounced than those on general obesity during weight regain.

Funding

Malene Revsbech Christiansen and Tuomas O. Kilpeläinen were supported by the Novo Nordisk Foundation grant number NNF18CC0034900. Malene Revsbech Christiansen was additionally supported by a research grant from the Danish Diabetes Academy, which is funded by the Novo Nordisk Foundation, grant number NNF17SA0031406. Tuomas O. Kilpeläinen was additionally supported by the Novo Nordisk Foundation grant numbers NNF20OC0063707 and NNF21SA0072102.

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