A comparative analysis of glycemic metrics derived from three continuous glucose monitoring (CGM) systems

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posted on 2025-04-08, 15:50 authored by Guido Freckmann, Stephanie Wehrstedt, Manuel Eichenlaub, Stefan Pleus, Manuela Link, Nina Jendrike, Sükrü Öter, Derek Brandt, Cornelia Haug, Delia Waldenmaier

Objective

This study analyzed the differences in continuous glucose monitoring (CGM)-derived metrics between three current-generation systems and evaluated their impact on therapeutic decision-making.

Research Design and Methods

23 participants wore the FreeStyle Libre 3, Dexcom G7 and Medtronic Simplera CGM systems for 14 days in parallel. CGM metrics were calculated for each participant and CGM system separately.

Results

The apparent glucose profile was influenced by the used CGM system, resulting in substantially different glycemic metrics between the three systems.

Agreement between FreeStyle Libre 3 and Dexcom G7 was higher than with Medtronic Simplera, which showed lower glucose levels on average. There were marked intra-participant discrepancies which would have resulted in different therapeutic recommendations.

Conclusions

The CGM systems indicated discordant glycemic metrics which should be considered in diabetes therapy. Different CGM systems should provide the same glucose readings and CGM-derived metrics when used by the same person.